Lance Franklin (bruised heel) and Dan Hannebery (groin) will miss Saturday night's clash against North Melbourne at the SCG.
The star duo missed Saturday's 17-point win over Geelong after being ruled out of the contest as they recover from injury.
Coach John Longmire said both players had already been ruled out of Saturday night's contest.
"They are both not going to be playing this week," Longmire told Channel Seven's Talking Footy.
"This afternoon the medical guys ruled them both out so they are not playing this week."
"Hannebery has a slight tear in his groin so he missed last week, will miss this week and we will see what he is like next week."
Franklin has been struggling for the past month with a bruised heel which sidelined him for the Swans' 17-point victory over Geelong at GMHBA Stadium on Saturday.
The 31-year-old sustained the injury against West Coast in round one and has been heavily restricted at training, although he was able to get through several games.
The club will provide a full HCF injury update on Tuesday afternoon at sydneyswans.com.au.
