The Sydney Swans have fallen to the Richmond Tigers at C.Ex Coffs International Stadium on Saturday afternoon with a 46-point loss.
The Tigers' pressure and slick ball-use overwhelmed the home side in the first quarter as a five-goal opening term laid the platform for the team's momentum.
Brennan's game-high tally of three majors was complemented by two each from Maddy Shevlin, Sarah Hosking and Mackenzie Ford.
Ellie McKenzie was best afield with a career-high 23 disposals, with Grace Egan (19 touches) and ruck Poppy Kelly (38 hitouts) also outstanding.
Montana Ham (two goals) was a shining light in attack for the Swans and Laura Gardiner worked tirelessly for a game-high 29 touches.
Sydney finally mustered a response when Ham kept her feet in a contest and slotted her first major early in the second quarter.
The midfield battle evened up before half-time, but Richmond maintained its buffer through efficiency in attack and were not threatened after the main break.
The result, in the first AFLW meeting between the sides, gave Richmond a 2-1 record, while Sydney (1-2) has now lost consecutive games after winning their season-opener against Collingwood.
Sydney will face the GWS Giants at Henson Park next Sunday, September 22.